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Our mission is to protect human health and the environment. EPA Region 5

serves Illinois, Indiana, Michigan, Minnesota, Ohio, Wisconsin and 35 Tribes.


Contact EPA Region 5

Region 5 Main Number: 312-353-2000

Call Region 5 toll-free at: 800-621-8431 

(The toll-free number only works in Illinois, Indiana, Michigan, Minnesota, Ohio, and Wisconsin.) Call us on weekdays from 8:00 am to 4:30 pm Central time. You can leave a message if you call outside of business hours.

Email: If you'd like a reply, please tell us how to reach you.


Mailing Address:
US EPA Region 5
77 W. Jackson Blvd.
Chicago, IL 60604

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